Integrated genomics identifies a new AT/RT-like yet INI1-positive brain tumor subtype among primary pediatric embryonal tumors

ABSTRACT: Pediatric embryonal brain tumor (PEBT), which includes medulloblastoma (MB), primitive neuroectodermal tumor (PNET) and atypical teratoid/rhabdoid tumor (AT/RT), is the second most prevalent pediatric tumor type among brain tumors of childhood. AT/RT is highly malignant and is often misdiagnosed as MB and PNET. Distinguishing AT/RT from PNET/MB is of clinical significance since the survival rate of AT/RT patients is much lower. The diagnosis of AT/RT relies primarily on the morphologic assessment and immunohistochemistry (IHC) staining on a few known markers such as the lack of INI1 protein expression. However, in our clinical practice we observed several AT/RT-like tumors, which fulfilled histopathologic and all other biomarker criteria for AT/RT diagnosis, still showed retained INI1 immu

ORGANISM(S): Homo sapiens

SUBMITTER: Tsung-Han Hsieh 

PROVIDER: E-GEOD-65132 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress