NF-κB activation impairs somatic cell reprogramming in ageing [NGPS_iPSCs]

ABSTRACT: Transcriptional profiling of human control and Néstor-Guillermo Progeria Syndrome (NGPS) fibroblasts and induced pluripotent stem cells (iPSCs). Somatic cell reprogramming involves rejuvenation of adult cells and relies on the ability to erase age-associated molecular marks. Accordingly, reprogramming efficiency declines with ageing, and age-associated features such as genetic instability, cell senescence or telomere shortening negatively affect this process. However, the regulatory mechanisms that constitute age-associated barriers for cell reprogramming remain largely unknown. Here, by using cells from patients with premature ageing, we demonstrate that NF-κB activation is a critical barrier for the generation of induced pluripotent stem cells (iPSCs) in ageing. We show that NF-κB repre

ORGANISM(S): Homo sapiens

SUBMITTER: Jose Freije 

PROVIDER: E-GEOD-65170 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress