Two-signal requirement for growth-promoting function of Yap

ABSTRACT: The transcriptional coactivator Yap promotes proliferation and inhibits apoptosis, suggesting that Yap functions as an oncogene. Most oncogenes, however, require a combination of at least two signals to promote proliferation. Here we present evidence that Yap activation is insufficient to promote growth in the otherwise normal tissue. Using a mosaic mouse model, we demonstrate that Yap overexpression in a fraction of hepatocytes does not lead to their clonal expansion, as proliferation is counterbalanced by increased apoptosis. To shift the activity of Yap towards growth, a second signal provided by tissue damage or inflammation is required. In response to liver injury, Yap drives clonal expansion, suppresses hepatocyte differentiation and promotes a progenitor phenotype. These results su

ORGANISM(S): Mus musculus

SUBMITTER: Xu Gao 

PROVIDER: E-GEOD-65207 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress