Robust Molecular Classification of Ependymal Tumors Across All Anatomic Compartments

ABSTRACT: Ependymal tumors across age groups have been classified solely by histopathology. It is, however, commonly accepted that this classification has limited clinical utility based on its poor reliability. We aimed at establishing a reliable and reproducible molecular classification using DNA methylation fingerprints of the tumors. Studying a cohort of 500 tumors allowed for the delineation of nine robust molecular subgroups, three in each anatomic compartment of the central nervous system (CNS). Two of the supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification by far and thus might serve as a basis for the u

ORGANISM(S): Homo sapiens

SUBMITTER: Martin Sill 

PROVIDER: E-GEOD-65362 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress