In depth characterization of the activity of a novel synthetic macrocyclic antifungal compound

ABSTRACT: The systemic infections by peptogenous fungi member of the genera Candida and Aspergillus represent a serious threat for public health. During previous research we have successfully identified a family of compounds active against different Candida spp. including strains resistant to antifungal drugs currently on the market. We have further refined our knowledge on this field by identifying a possible molecular target that could justify the activity of these compounds. The research of the mode of action of the compounds object of this manuscript was supported also by fluorescent microscopy of labeled derivatives. Transcriptional data indicates that one of the macrocyclic antifungal induces a drug response involving ATP binding cassette transporters. Moreover the data show that the macrocycl

ORGANISM(S): Candida albicans

SUBMITTER: Dominique Sanglard 

PROVIDER: E-GEOD-65396 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress