Transcription profiling of rat cardiac injury: a potential link to air pollution mortality?

ABSTRACT: Zinc (Zn) is a major elemental component of respirable ambient particulate matter (PM) detected often at alarming levels in urban air. Exposure to PM has been widely associated with increased cardiovascular morbidity and mortality, however, it is not known what components or sources of PM are causative. We recently demonstrated that long-term episodic inhalation of combustion PM, having similar amount of Zn found in urban PM, caused myocardial lesions in rats. We further demonstrated that a single pulmonary exposure to Zn at high concentration is associated with disturbances in cardiac mitochondrial function, ion channel regulation, calcium homeostasis, and cell signaling. Therefore, in this study we investigated the role of PM-associated Zn in cardiac injury using multiple exposure scenar

ORGANISM(S): Rattus norvegicus

SUBMITTER: Urmila Kodavanti 

PROVIDER: E-GEOD-6541 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress