Transcription profiling of C. elegans pocket protein ortholog, lin-35

ABSTRACT: LIN-35 is the single C. elegans ortholog of the mammalian pocket protein family members, pRb, p107, and p130. To gain insight into the roles of pocket proteins during development, a microarray analysis was performed with lin-35 mutants. Stage-specific regulation patterns were revealed, indicating that LIN-35 plays diverse roles at distinct developmental stages. LIN-35 was found to repress the expression of many genes involved in cell proliferation in larvae, an activity that is carried out in conjunction with E2F. In addition, LIN-35 was found to regulate neuronal genes during embryogenesis and targets of the intestinal-specific GATA transcription factor, ELT-2, at multiple developmental stages. Additional findings suggest that LIN-35 functions in cell cycle regulation in embryos in a mann

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: David Fay 

PROVIDER: E-GEOD-6547 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress