The TCR activation acts as a tumor suppressor mechanism in T-ALL

ABSTRACT: Developmental checkpoints in stem/progenitor cells are critical to the determination, commitment and differentiation into distinct lineages. Cancer cells often retain expression of lineage-specific checkpoint proteins, but their potential impact in cancer remains elusive. T lymphocytes mature in the thymus following a highly orchestrated developmental process that entails the successive rearrangements and expression of T-cell receptor (TCR) genes. Low affinity recognition of self-peptide/MHC complexes (self-pMHC) presented by thymic epithelial cells by the TCR of CD4+CD8+ (DP) cortical thymocytes transduces positive selection signals that ultimately shape the developing T cell repertoire. DP thymocytes not receiving these signals die by lack of stimulation whereas those that recognize self

ORGANISM(S): Homo sapiens

SUBMITTER: Mohamed BELHOCINE 

PROVIDER: E-GEOD-65496 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress