Tenascin-C Protects Cancer Stem-Like Cells from Immune Surveillance

ABSTRACT: Precociously disseminated cancer cells may seed quiescent sites of future metastasis if they can protect themselves from immune surveillance. However, there is little knowledge about how such sites might be achieved. Here we present evidence that prostate cancer stem-like cells (CSC) can be found in histopathologically negative prostate draining lymph nodes (PDLN) in mice harboring oncogene-driven prostate intraepithelial neoplasia (mPIN). PDLN-derived CSC were phenotypically and functionally identical to CSC obtained from mPIN lesions, but distinct from CSCs obtained from frank prostate tumors. CSC derived from either PDLN or mPIN used the extracellular matrix protein Tenascin-C (TNC) to inhibit T cell receptor-dependent T cell activation, proliferation and cytokine production. Mechanisti

ORGANISM(S): Mus musculus

SUBMITTER: Ignazio Piras 

PROVIDER: E-GEOD-65502 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress