MiR-200 overexpression in colorectal cancer lines

ABSTRACT: Unsupervised classification of gene expression profiles has resulted in the identification of biologically and clinically distinct colon cancer subtypes (CCSs). The subtype that associates with poor clinical outcome displays a mesenchymal gene expression profile. No driver mutation has been identified for this category and patients are heterogeneous with regard to commonly used clinical markers. Here we report a regulatory network consisting of the miR-200 family members that tunes the majority of genes differentially expressed in the poor prognosis CCS, including genes involved in the epithelial-mesenchymal transition (EMT) process. Our data indicate that the epigenetic silencing of the miR-200 family by promoter methylation is identifying the mesenchymal CCS and is predictive of disease-

ORGANISM(S): Homo sapiens

SUBMITTER: Louis Vermeulen 

PROVIDER: E-GEOD-65551 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress