Mechanosensitive proteins are sensitized in myelinated afferents following in vivo inflammation

ABSTRACT: Here we identified two populations of myelinated sensory neurons that display markedly different phenotypes in terms of their action potential characteristics and responses to mechanical stimuli based on their expression of Calcitonin Gene-Related Peptide (CGRP). Myelinated neurons that did not express CGRP responded to mechanical stimuli with significantly larger currents during whole-cell voltage clamp recordings than their CGRP-positive counterparts, regardless of whether these neurons projected to the dorsal hindpaw skin or the gastrocnemius muscle. Importantly, this discrepancy could not be explained by a differential expression of mechanosensitive or mechanically-gated proteins like Stoml3 or Piezo2. Following inflammation of the skin or muscle, myelinated neurons demonstrated a sens

ORGANISM(S): Mus musculus

SUBMITTER: Andy Weyer 

PROVIDER: E-GEOD-65613 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress