Lymphatic vessels arise from a niche of multipotent angioblasts within the floor of the cardinal vein

ABSTRACT: How cells acquire their fate is a fundamental question in both developmental and regenerative biology. Multipotent progenitors undergo gradual cell fate restriction in response to temporal and positional cues from the microenvironment, the nature of which is far from being clear. In the case of the lymphatic system, venous endothelial cells are thought to give rise to lymphatic vessels, through a process of trans-differentiation. Upon expression of a set of transcription factors, venous cells acquire a lymphatic fate, and bud out to generate the lymphatic vasculature. In this work we challenge this view and show that while lymphatic endothelial cells (LECs) do arise in the Cardinal Vein (CV), they do so from a previously uncharacterized pool of multipotent angioblasts. Using lymphatic-spec

ORGANISM(S): Danio rerio

SUBMITTER: Anatoly Senderovich 

PROVIDER: E-GEOD-65751 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress