Gene expression profile in CD4+ T-cell infection with a SIV mutant related to altered humoral immune responses

ABSTRACT: A mutant simian immunodeficiency (SIVmac239) virus, found to be selected within chronically SIV-infected Burmese rhesus monkeys with relatively enhanced SIV-specific antibody responses, was reconstituted as a molecular clone. The virus (SIV Nef G63E) was then subjected to a preliminary analysis for their intracellular signal transduction and gene expression modulation patterns (as compared with wild type SIVmac239) within infected CD4+ T cells. Analysis implicated that the mutant virus had a moderately enhanced cytopathic phenotype. A SIV mutation (SIVmac239 Nef G63E) found to be enriched in rhesus monkeys with enhanced SIV-specific antibody responses was reconstituted on a pBR-based SIV molecular clone pBRmac239. HSC-F cynomolgus macaque central memory Th2-like T cells were infected with

ORGANISM(S): Homo sapiens

SUBMITTER: Hiroyuki Yamamoto 

PROVIDER: E-GEOD-65806 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress