Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Manuel Irimia
PROVIDER: E-GEOD-65818 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Genes & development 20150401 7
Alternative splicing (AS) generates vast transcriptomic complexity in the vertebrate nervous system. However, the extent to which trans-acting splicing regulators and their target AS regulatory networks contribute to nervous system development is not well understood. To address these questions, we generated mice lacking the vertebrate- and neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100/SRRM4). Loss of nSR100 impairs development of the central and peripheral nervous systems in ...[more]