Transcriptomic response in colon of rat with increased dietary protein content

ABSTRACT: Increase of fecal hazardous compounds and decrease of butyrate-producing bacteria has been implicated to be detrimental to colonic health during weight loss by high-protein diet in human. The question remains that whether the change of luminal microenvironment were paralleled with the alteration of colonic function in vivo.To reveal the change of gene expression involved in metabolic or immmunological process, we have employed the whole genome microarray profiling to identify differentially expressed genes in rat dietary normal protein (20% protein) or high protein (45% protein) diet. Colonic epithelium were sampled in adult male wistar rats (weighing 180-200g) fed each diet for six weeks.Each group contained six replicates.A total of 181 transcripts were significantly changed: 88 genes we

ORGANISM(S): Rattus norvegicus

SUBMITTER: Weiyun Zhu 

PROVIDER: E-GEOD-65862 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress