H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription

ABSTRACT: Hormone-dependent gene expression requires dynamic and coordinated epigenetic changes. Estrogen receptor-positive (ER+) breast cancer is particularly dependent upon extensive chromatin remodeling and changes in histone modifications for the induction of hormone-responsive gene expression. Our previous studies established an important role of bromodomain-containing protein-4 (BRD4) in promoting estrogen-regulated transcription and proliferation of ER+ breast cancer cells. Here, we investigated the association between genome-wide occupancy of histone H4 acetylation at lysine 12 (H4K12ac) and BRD4 in the context of estrogen-induced transcription. Similar to BRD4, we observed that H4K12ac occupancy increases near the transcription start sites (TSS) of estrogen-induced genes as well as at dista

ORGANISM(S): Homo sapiens

SUBMITTER: Steven Johnsen 

PROVIDER: E-GEOD-65886 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress