Bacterial c-di-GMP reorganizes hematopoietic stem/progenitors and niches through STING

ABSTRACT: Upon systemic bacterial infection, hematopoietic stem and progenitor cells (HSPCs) migrate to the periphery in order to supply a sufficient number of immune cells. Although pathogen-associated molecular patterns (PAMPs) reportedly mediate HSPC activation, how HSPCs detect pathogen invasion in vivo remains elusive. Bacteria use the second messenger bis-(3’-5’)-cyclic dimeric guanosine monophosphate (c-di-GMP) for a variety of activities. Here we report that c-di-GMP comprehensively regulates both HSPCs and their niche cells through an innate immune sensor, STING, thereby inducing entry into the cell cycle and mobilization of HSPCs, while decreasing the number and repopulation capacity of long-term hematopoietic stem cells (LT-HSCs). Furthermore, we show that type I IFN acts as a downstream

ORGANISM(S): Mus musculus

SUBMITTER: Keiyo Takubo 

PROVIDER: E-GEOD-65905 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress