Transcription profiling of three cutaneous rosacea subtypes to characterize the inflammatory infiltrate

ABSTRACT: Rosacea is a common chronic inflammatory skin disease of unknown etiology. Our knowledge about an involvement of the adaptive immune system is very limited. We performed detailed transcriptome analysis, qRT-PCR, and quantitative immunohistochemistry on facial biopsies of rosacea patients, classified according to their clinical subtype. As controls, we used samples from healthy controls. Our study shows significant activation of the immune system in all subtypes of rosacea, characterizing erythematotelangiectatic rosacea (ETR) already as a disease with significant influx of proinflammatory cells. The T cell response is dominated by Th1/Th17-polarized immune cells, as demonstrated by significant upregulation of IFNγ or IL-17, for example. Chemokine expression patterns support a Th1/Th17 p

ORGANISM(S): Homo sapiens

SUBMITTER: Isabelle Carlavan 

PROVIDER: E-GEOD-65914 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress