Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed

ABSTRACT: Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using these and other available data, we discovered and analyzed thousands of neuronal human and mouse circRNAs. circRNAs were extraordinarily enriched in the mammalian brain, well conserved in sequence, often expressed as circRNAs in both human and mouse, and sometimes even detected in Drosophila brains. circRNAs were overall upregulated during neuronal differentiation, highly enriched in synapses, and often differentially expressed compared to their mRNA isoforms. circRNA expression correlated negati

ORGANISM(S): Homo sapiens

SUBMITTER: Nikolaus Rajewsky 

PROVIDER: E-GEOD-65926 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress