Gene expression profiling of IOERT exposed MCF10A breast epithelial cells

ABSTRACT: Intraoperative Electron Radiation Therapy (IOERT) is a therapeutic technique that delivers a single high dose of ionizing radiation (IR) directly to the tumor bed during cancer surgery. The main goal of IOERT is to counteract tumor growth by acting on residual cancer cells in the site at high risk for recurrence as well as to preserve healthy surrounding tissue from the side effects of radiation therapy. The high IR dose used during IOERT treatment induces a strong stress response resulting in the activation of pro- and anti-proliferative cell signaling pathways in both tumor and normal cells. The radiobiology of healthy tissue response to IR is a topic of interest which may contribute to avoid the impairment of normal tissue/organ function and to decrease the risks of secondary cancers. I

ORGANISM(S): Homo sapiens

SUBMITTER: Valentina Bravatà 

PROVIDER: E-GEOD-65954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress