The contribution of Alu exons to the human proteome

ABSTRACT: Alu element is a major contributor to lineage-specific new exons in the primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important regulatory roles in modulating mRNA degradation or translational efficiency. However, the contribution of Alu exons to the human proteome remains unclear and controversial. The prevailing view is that exons derived from young repetitive elements (such as Alu) are restricted to regulatory functions but do not have adequate evolutionary time to be incorporated into stable, functional proteins. In this work, we adopt a proteotranscriptomics approach to systematically assess the contribution of Alu exons to the human proteome. Using RNA sequencing, ribosom

ORGANISM(S): Homo sapiens

SUBMITTER: Jinkai Wang 

PROVIDER: E-GEOD-65999 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress