Transcription profiling of human metastatic prostate tumor

ABSTRACT: Prostate cancer is characterized by heterogeneity in the clinical course that often does not to correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can reliably predict which patients are at higher risk of developing metastatic disease. Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets. Using Affymetrix oligonucleotide arrays, we analyzed gene expression profiles of 24 androgen-ablation resistant metastatic samples obtained from 4 patients and a previously published dataset of 64 primary prostate tumor samples. Differential gene expr

ORGANISM(S): Homo sapiens

SUBMITTER: Federico Alberto Monzon 

PROVIDER: E-GEOD-6605 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress