Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Mcl-1 is a key determinant of breast cancer cell survival [copy number]

ABSTRACT: Copy number profile of cultured Breast Cancer cell line measured by Affymetrix SNPs microarrays Whole genome copy number profile of 2 breast cancer cell lines were analyzed using Affymetrix SNP6.0 arrays

ORGANISM(S): Homo sapiens

SUBMITTER: Xin Lu 

PROVIDER: E-GEOD-66070 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor.

Xiao Yu Y   Nimmer Paul P   Sheppard George S GS   Bruncko Milan M   Hessler Paul P   Lu Xin X   Roberts-Rapp Lisa L   Pappano William N WN   Elmore Steven W SW   Souers Andrew J AJ   Leverson Joel D JD   Phillips Darren C DC  

Molecular cancer therapeutics 20150526 8

Hyperexpression of antiapoptotic BCL-2 family proteins allows cells to survive despite the receipt of signals that would ordinarily induce their deletion, a facet frequently exploited by tumors. Tumors addicted to the BCL-2 family proteins for survival are now being targeted therapeutically. For example, navitoclax, a BCL-2/BCL-XL/BCL-W inhibitor, is currently in phase I/II clinical trials in numerous malignancies. However, the related family member, MCL-1, limits the efficacy of navitoclax and  ...[more]

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