Genome-wide profiling of H3K56ac in Drosophila melanogaster Kc167 cell lines with Lz overexpression

ABSTRACT: The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target-selection and gene activation in each context. To investigate, we partitioned Drosophila chromatin into different states, based on histone modifications, establishing the preferred chromatin conditions for binding of CSL, the Notch pathway transcription factor and showing that a co-operating factor, Lozenge/Runx, can help establish these conditions. While most histone modifications were unchanged by CSL binding or Notch activation, rapid changes in H3K56 acetylation occurred at Notch regulated-enhancers. This modification extended over large regions, required the histone acetyl-transferase CBP and was independent of transcription. Such rapid change

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Sarah Bray 

PROVIDER: E-GEOD-66223 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress