Genome-wide profiling of Su(H) in Drosophila melanogaster BG3 cell lines

ABSTRACT: The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target-selection and gene activation in each context. To investigate, we partitioned Drosophila chromatin into different states, based on histone modifications, establishing the preferred chromatin conditions for binding of CSL, the Notch pathway transcription factor. While most histone modifications were unchanged by CSL binding or Notch activation, rapid changes in H3K56 acetylation occurred at Notch regulated-enhancers. This modification extended over large regions, required the histone acetyl-transferase CBP and was independent of transcription. Such rapid changes in H3K56 acetylation are a conserved indicator of enhancer activation, also occurring at

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Sarah Bray 

PROVIDER: E-GEOD-66225 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress