Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio

ABSTRACT: Background: Exposure to dichlorvos (DDVP), an organophosphorus pesticide, is known to result in neurotoxicity as well as other metabolic perturbations. However, the molecular causes of DDVP toxicity are poorly understood, especially in cells other than neurons and muscle cells. To obtain a better understanding of the process of non-neuronal DDVP toxicity, we exposed zebrafish to different concentrations of DDVP, and investigated the resulting changes in liver histology and gene transcription. Results: Functional enrichment analysis of genes affected by DDVP exposure identified a number of processes involved in energy utilization and stress response in the liver. The abundance of transcripts for proteins involved in glucose metabolism was profoundly affected, suggesting that carbon flux

ORGANISM(S): Danio rerio

SUBMITTER: Christine Baer 

PROVIDER: E-GEOD-66257 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress