Comprehensive Analysis of Recurrence-Associated Small Non-Coding RNAs in Esophageal Cancer [clinical study, Illumina]

ABSTRACT: Targeted cancer therapy for squamous cell carcinoma (SCC) has made little progress largely due to a lack of knowledge of the driving genomic alterations. Small non-coding RNAs (sncRNAs) as a potential biomarker and therapeutic target to SCC remain a challenge. We analyzed sncRNAs microarray in 108 fresh frozen specimens of esophageal squamous cell carcinoma (ESCC) as discovery set and assessed associations between sncRNAs and recurrence-free survival. SncRNA signature identified was externally validated in two independent cohorts. We investigated the functional consequences of sncRNA identified and its integrative analysis of complex cancer genomics. We identified 3 recurrence-associated sncRNAs (miR-223, miR-1269a and nc886) from discovery set and proved risk prediction model externally i

ORGANISM(S): Homo sapiens

SUBMITTER: Hyun-Sung Lee 

PROVIDER: E-GEOD-66258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress