Myelodysplastic syndrome: NUP98-HoxD13 (NHD13) expression effect on hematopoietic stem cells

ABSTRACT: Analysis of Lin-c-Kit+Sca-1- haematopoietic stem cells (HSCs) expressing the Nup98-HoxD13 (NHD13) fusion gene. NHD13 induces myelodysplastic syndrome (MDS) in mice. Results provide insight into the molecular basis of the myelodysplastic phenotype WT mouse HSCs were compared to an NHD13 mutant sequenced in triplicate on a HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: David Powell 

PROVIDER: E-GEOD-66264 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress