Taqman miRNA Array on Murine livers with varying amounts of carbon tetrachloride induced liver fibrosis

ABSTRACT: Abstract from Knabel et al. PLoS One (2015): Fibrosis refers to the accumulation of excess extracellular matrix (ECM) components and represents a key feature of many chronic inflammatory diseases. Unfortunately, no currently available treatments specifically target this important pathogenic mechanism. MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally repress target gene expression and the development of miRNA-based therapeutics is being actively pursued for a diverse array of diseases. Because a single miRNA can target multiple genes, often within the same pathway, variations in the level of individual miRNAs can potently influence disease phenotypes. Members of the miR-29 family, which include mir29a, miR-29b and miR-29c, are strong inhibitors of ECM synthesis and

ORGANISM(S): Mus musculus

SUBMITTER: Tyler Creamer 

PROVIDER: E-GEOD-66278 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress