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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from adult male Sprague Dawley rat liver, investigating how pomegranate skin extract prevents non alcoholic fatty liver diseases

ABSTRACT: Pomegranate skin extract could prevent fatty liver due to high fat diet in adult male Sprague Dawley rat. There are 3 groups of rats, feeding chow diet, high fat diet and high fat diet combined with pomegrante skin extract. After 8 weeks feeding, high fat diet group developped fatty liver but the other two groups still have healthy liver. We used microarrays to detail the global programme of gene expression underlying the fatty liver development and preventive effect of pomegranate skin extract on fatty liver. There are 3 treatment groups and 6 replicates for each group. The 3 treatment groups are control group feeding chow diet, high fat group feeding high fat diet and PE group feeding high fat diet and pomegranate skin extract. Rat livers were collecteded for RNA extraction and hybridization on Affymetrix microarrays.

ORGANISM(S): Rattus norvegicus

SUBMITTER: yujie shi

PROVIDER: E-GEOD-66316 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data from adult male Sprague Dawley rat liver, investigating how pomegranate skin extract prevents non alcoholic fatty liver diseases

Project description:Pomegranate skin extract could prevent fatty liver due to high fat diet in adult male Sprague Dawley rat. There are 3 groups of rats, feeding chow diet, high fat diet and high fat diet combined with pomegrante skin extract. After 8 weeks feeding, high fat diet group developped fatty liver but the other two groups still have healthy liver. We used microarrays to detail the global programme of gene expression underlying the fatty liver development and preventive effect of pomegranate skin extract on fatty liver.

2016-02-01 | GSE66316 | GEO

Transcriptome analysis of the livers from mice that had been fed water-soluble extract of Pacific Krill

Project description:Background: We previously reported that intake of a water-soluble extract of Pacific Krill (WEPAK) by mice decreases triglyceride accumulation in liver and suppresses weight gain induced by a high-fat diet. However, the mechanisms mediating these phenomena were not investigated or revealed in our previous study. Methods and Findings: Here, we investigated the effect of WEPAK in mouse liver using transcriptome analysis and discovered that WEPAK induced the expression of genes categorized into the gene ontology (GO) term lipid metabolic process. Furthermore, two regulators of fatty acid Î²-oxidation, AMPK and PPARÎ´, were induced in the liver and muscle of mice that had taken in WEPAK. Conclusions: These results indicate that WEPAK increased the expression of genes related to fatty acid Î²-oxidation via activation of AMPK and PPARÎ´. WEPAK may have the effect of improving lipid metabolism and, therefore, may be beneficial in the prevention of obesity. Examination of 4 different feeding condtion (4mice/group)

2013-04-22 | E-GEOD-37379 | biostudies-arrayexpress

Quantitative analysis of standard diet and high fat diet-fed wild type and Sirt3 knockout mouse pancreatic islets transcriptomes.

Project description:To explore the underlying mechanism for the regulatory role of SIRT3 in pancreatic islets under standard and high fat diet feeding, we conducted RNA sequencing on the isolated islets from standard diet and high fat diet-fed wild type and pancreatic beta cell selective Sirt3 knockout mice (four groups in total). Three biological replicates were performed for each group.

2022-08-15 | GSE156345 | GEO

Gene expression in diet-induced obesity resistent (DIO non-responder) and diet-induced obesity susceptible (DIO responder) C57BL/6J mouse strain

Project description:Inbred C57BL/6J mice differ in their susceptibility to diet-induced obesity. Comparison of the liver transcriptomes leads to genes that are involved in the development as well as the maintenance of fatty liver during the onset of obesity upon high fat diet feeding. Genes being upregulated in DIO responder can be seen as drivers of fatty liver development, while genes upregulated in DIO non-responder are most likely involved in the protection against fatty liver diseases.

2018-10-30 | GSE74542 | GEO

Estrogen signaling and fatty liver disease

Project description:We propose comparing liver gene expression of WT and female ERKO mice early in the high-fat feeding period to animals fed a regular chow diet. Analyzing liver tissue before the fatty liver disease phenotype becomes severe will allow identification of target genes which may be causal. Comparison of regular chow fed WT animals to high fat fed WT animals will allow for identification of hepatic genes up-regulated in response to high fat feeding. Comparison of regular chow fed WT animals to regular chow fed ERKO animals will help clarify hepatic gene expression patterns that may be implicated in increased susceptibility to weight gain and glucose intolerance. Comparison of high fat fed WT animals to high fat fed ERKO animals will provide insight into genes that could be implicated in leading to increased fat accumulation in the liver over time during high fat feeding. Finally, comparison of regular chow fed ERKO animals to high fat fed ERKO animals will help identify genes that may be contributing to increased liver fat accumulation in response to high fat feeding in these animals.

2017-03-22 | GSE95283 | GEO

Coordinated changes of gut microbiome and lipidome differentiates nonalcoholic steatohepatitis (NASH) from isolated steatosis

Project description:Following 21-week of high fat diet (HFD)-feeding, obese mice were classified into two groups termed as isolated steatosis and NASH based on H&E staining of liver

2022-02-20 | GSE126790 | GEO

Growth, blood biochemistry, histology and transcriptomic profile analysis influences liver fat deposition and inflammation process following dietary supplementation of apple peel powder in Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus)

Project description:GIFT is a type of freshwater farmed fish with high economic value and nutritional value. The liver is an important organ of fish metabolism. Once it is damaged or the disease occurs, it will lead to metabolic disorders and decreased disease resistance, and may cause other secondary diseases. In the high-density intensive culture of tilapia, the feed nutrition is not balanced, especially the addition of high-fat feed. High fat content can accelerate the growth of fish, but long-term feeding of high-fat diet can lead to metabolic disorders of fish, accumulation of fat in the body, easy to cause fatty liver, and ultimately death due to liver necrosis or hemorrhage, seriously affecting the breeding benefits. The main purpose of this study was to investigate the effects of apple peel added to feed on liver fat metabolism and fat deposition in tilapia tilapia; use transcriptomics to analyze related signal regulation pathways, focusing on fat metabolism and inflammatory response; and finally screening differentially expressed genes. The development of this study is helpful to understand the molecular mechanism of apple peel extract powder-mediated liver fat metabolism and inflammatory response in GIFT, and relieve liver stress. It also provides theoretical support for the application of apple peel extract powder as a feed additiion in aquatic products.

2019-12-04 | GSE127810 | GEO

WTCHG - Mouse - Liver Gene Expression Response to Prolonged Fat Feeding

Project description:The effect of high fat diet feeding on liver gene transcription regulation was investigated in C57BL/6J mice using Affymetrix gene expression arrays. Expression data was determined in 5 months old male mice fed a high fat diet (40% fat) for 15 weeks. Control mice were fed a standard carbohydrate chow. Six animals per group were used.

2008-08-18 | E-MEXP-1755 | biostudies-arrayexpress

WTCHG - Mouse - Liver transcriptome adaptations to high fat diet

Project description:The effect of high fat diet feeding on liver gene transcription regulation was investigated in BALB/c mice using Affymetrix gene expression arrays. Expression data was determined in 5 months old male mice fed a high fat diet (40% fat) for 15 weeks. Control mice were fed a standard carbohydrate chow. Six animals per group were used.

2012-01-11 | E-MTAB-488 | biostudies-arrayexpress

Effect of Concentration and type of Dietary Fatty Acid on Development of Nonalcoholic Fatty Liver Disease

Project description:The current study was designed to determine if dietary fatty acid concentration and composition affects the development and progression of nonalcoholic fatty liver disease. Male SD rats were overfed diets low (5%) or high (70%) fat diets via total enteral nutrition where the fat source was olive oil (monounsaturated), or corn oil (polyunsaturated). Overfeeding 5% corn oil produced little steatosis relative to feeding 5% olive oil. This was associated with lower fatty acid synthesis and reduced SREBP-c signaling in the 5% corn oil group. Overfeeding 70% fat diets increased steatosis and lead to increased liver necrosis in the 70% corn oil but not olive oil group. Increased injury after feeding polyunsaturated fat diets was linked to peroxidizability of hepatic free fatty acids and triglycerides and appearance of peroxidaized lipid products HETES and HODES previously linked to clinical nonalcoholic steatohepatitis. Male SD rats were overfed diets low (5%) or high (70%) fat diets via total enteral nutrition where the fat source was olive oil (monounsaturated) or corn oil (polyunsaturated).

2011-10-23 | E-GEOD-33166 | biostudies-arrayexpress

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