Nitric oxide regulates gene expression in cancers by controlling histone posttranslational modifications [PrimeView]

ABSTRACT: Dynamic changes in histone posttranslational modifications (PTMs) are important regulators of chromatin structure and gene transcription in both normal and disease settings. Herein, we describe a novel signaling mechanism of nitric oxide (â?¢NO) by demonstrating its ability to modulate gene expression via alteration of histone PTMs. Having established that â?¢NO exposure induced differential expression of approximately 6500 genes, we set out to determine if there was an epigenetic component to their regulation. â?¢NO exposure led to alterations in the global levels of acetyl and methyl modifications at numerous lysine residues on core histones H3 and H4. Residues H3K9me2/ac were examined further and determined to have differential distribution at various loci throughout the genome in respo

ORGANISM(S): Homo sapiens

SUBMITTER: Douglas Thomas 

PROVIDER: E-GEOD-66322 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress