Epigenomic Evolution of Diffuse Large B-cell Relapse

ABSTRACT: Here we characterize an association between disease progression and DNA methylation in Diffuse Large B cell Lymphoma (DLBCL). By profiling genome-wide DNA methylation at single base-pair resolution in thirteen DLBCL diagnosis-relapse sample pairs, we show DLBCL patients exhibit heterogeneous evolution of tumor methylomes during relapse. We identify differentially methylated regulatory elements and determine a relapse–associated methylation signature converging on key pathways such as transforming growth factor beta (TGF-beta) receptor activity. We also observe decreased intra-tumor methylation heterogeneity from diagnosis to relapsed tumor samples. Relapse-free patients display lower intra-tumor methylation heterogeneity at diagnosis compared to relapsed patients in an independent validat

ORGANISM(S): Homo sapiens

SUBMITTER: Yanwen Jiang 

PROVIDER: E-GEOD-66329 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress