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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Sumoylation coordinates repression of inflammatory and anti-viral gene programs during innate sensing

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Adrien Decque

PROVIDER: E-GEOD-66339 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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H3K4me3 chromatin profiling in SUMOylation-competent and -deficient bone marrow derived dendritic cells unstimulated or stimulated with LPS

Project description:Purpose: To determine H3K4me3 chromatin profile in UBC9WT and UBC9KO BMDC before and after LPS stimulation. Methods: H3K4me3 chromatin profile was determined by sequencing UBC9 WT and UBC9 KO BMDC chromatin immunoprecipitated with antibody specific for H3K4me3. Results: We show differential chromatin profile for H3K4me3 on the ifnb1 locus between UBC9 KO cells and UBC9 WT. Conclusions: Loss of SUMOylation causes a deregulation of ifnb1 transcription activation mark. A study of H3K4me3 chromatin profile in UBC9 WT and UBC9 KO Bone Marrow derived Dendritic Cells.

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Gene expression during SMC cord morphogenesis

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2010-03-23 | E-GEOD-20333 | biostudies-arrayexpress

Genome-wide analysis of RARÎ² transcriptional targets in mouse striatum links retinoic acid signaling with Huntingtonâs disease and other neurodegenerative disorders

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