Gene expression patterns in IgG4-RD before and after steroid treatment and healthy control groups

ABSTRACT: Transcriptome analysis in patients with IgG4-RD and healthy controls IgG4-related disease (IgG4-RD) is a new emerging disease entity characterized by elevated serum IgG4 concentrations and tissue tumefaction or infiltration by IgG4-positive plasma cells. At present, however, it is not clear whether IgG4-RD is caused by abnormalities in acquired immunity, like autoimmune diseases, or whether the excess production of IgG4 is a true cause of IgG4-RD or an epiphenomenon associated with inflammatory and/or allergic reactions. We therefore attempted to identify genes related to the pathogenesis or clinicopathology of IgG4-RD. Peripheral blood mononuclear cells (PBMCs) were obtained from patients with IgG4-RD before and after steroid therapy and from healthy controls. Total RNA was extracted and

ORGANISM(S): Homo sapiens

SUBMITTER: Akio Nakajima 

PROVIDER: E-GEOD-66465 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress