Interferon-γ response against C. burnetii of peripheral blood mononuclear cells in the development of chronic Q fever

ABSTRACT: Background: Q fever is caused by the Coxiella burnetii, an intracellular bacterium that infects mononuclear cells. In some individuals, it causes a persistent cardiovascular infection (chronic Q fever). The aim of present study was to investigate the C. burnetii-induced IFN-γ response in chronic Q fever patients. Methods: IFN-γ was measured in supernatants of C. burnetii-stimulated peripheral blood mononuclear cells (PBMCs) of patients. Gene-expression profiles of the IFN-γ pathway in PBMCs after incubation with C. burnetii were compared between chronic Q fever patients and control individuals. Results: IFN-γ production by PBMCs of chronic Q fever patients incubated with C. burnetii in vitro, was significantly higher compared to controls. In transcriptome analysis, genes downstream of

ORGANISM(S): Homo sapiens

SUBMITTER: Julien Textoris 

PROVIDER: E-GEOD-66476 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress