Genes differentailly expressed in organ-specific metastatic cells derived from MDA-MB-231 breast cancer cell line

ABSTRACT: Breast cancer metastasizes to bone, visceral organs, and/or brain depending on the subtypes. Various cell line models have been used to develop gene expression signatures unique to cancer cells that have metastasized to specific organs, although these efforts were not in a uniform setting. In this study, we compared gene expression pattern in MDA-MB-231 cells and its mammary fat pad tumor (TMD-231), lung metastasis (LMD-231), bone metastasis (BMD-231), adrenal metastasis (ADMD-231) and brain metastasis (231-BR) variants grown under the same growth condition. When gene expression differences between metasteses (p value of <0.01) were compared, 231-BR cells showed the highest gene expression difference (633 genes) followed by ADMD-231 (196 genes), LMD-231 (79 genes), and BMD-231 cells (60 ge

ORGANISM(S): Homo sapiens

SUBMITTER: Chirayu Goswami 

PROVIDER: E-GEOD-66495 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress