Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling time series of orotic acid induced fatty liver disease in Rattus norvegicus

ABSTRACT: A time course of orotic acid induced fatty liver disease. Kyoto and Wistar strain rats were exposed to orotic acid for days 1, 3 and 14. Controls are also included.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Julian Griffin

PROVIDER: E-GEOD-665 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver.

Griffin Julian L JL Bonney Stephanie A SA Mann Chris C Hebbachi Abdul M AM Gibbons Geoff F GF Nicholson Jeremy K JK Shoulders Carol C CC Scott James J

Physiological genomics 20040413 2

In functional genomics, DNA microarrays for gene expression profiling are increasingly being used to provide insights into biological function or pathology. To better understand the significance of the multiple transcriptional changes across a time period, the temporal changes in phenotype must be described. Orotic acid-induced fatty liver disease was investigated at the transcriptional and metabolic levels using microarrays and metabolic profiling in two strains of rats. High-resolution 1H-NMR ...[more]

PMID: 14747661

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Dataset Information

Transcription profiling time series of orotic acid induced fatty liver disease in Rattus norvegicus

Publications

An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver.

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