DNA Methylation Sequencing of Prostate Tumors Reveals Possible Molecular Mechanisms for Cancer Aggressiveness

ABSTRACT: A major challenge in the clinical management of prostate cancer is the inability to definitively diagnose indolent versus aggressive cases. Contributing to this challenge is a lack of basic science understanding of the molecular basis behind aggressiveness subtypes in prostate cancer. DNA methylation is the epigenetic addition of a methyl group to the DNA base cytosine and has been found to regulate cell proliferation and environmental adaptation. We hypothesized that DNA methylation changes are a mechanism by which an aggressive cancer attains phenotypes that distinguish it from indolent cases via disruption of regulatory networks. This hypothesis was tested by comparing DNA methylation between benign prostate and both low grade (Gleason score 6) and high grade (Gleason score 8 to 10) gro

ORGANISM(S): Homo sapiens

SUBMITTER: Jeffrey Bhasin 

PROVIDER: E-GEOD-66505 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress