Hepatitis B virus-mediated alterations to the primary hepatocyte transcriptome [24 and 48 h]

ABSTRACT: Purpose: Chronic infection with hepatitis B virus is the leading global risk factor for the development of liver cancer. A large body of research has shown the many effects an HBV infection has on cellular physiology, particularly on pathways that may be involved in the development of HBV-associated diseases. Unfortunately, a significant portion of this research has been done in systems that may not mimic what is seen in a primary hepatocyte, and is not done on a transcriptome-wide scale. Because of this, we performed an RNA-seq analysis of primary rat hepatocytes expressing HBV to determine the global changes HBV has on primary hepatocyte physiology. Methods: To do this RNA-seq analysis, triplicate samples of total RNA were collected from cultured primary rat hepatocytes infected with

ORGANISM(S): Rattus norvegicus

SUBMITTER: Michael Bouchard 

PROVIDER: E-GEOD-66566 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress