Insights into responses of human astrocytes to H5N1 infection by transcriptional analysis

ABSTRACT: Increasing evidence demonstrates influenza virus can not only affect the respiratory system, but also infect CNS and lead to CNS disorder and encephalopathy and encephalitis. Astrocytes are the most abundant cells in the CNS, which are capable of producing cytokines and neurotrophic factors and are essential for brain homeostasis and neuronal function. Previous studies suggested that influenza virus can infect astrocytes and induce proinflammatory cytokines response as well as apoptosis. Nevertheless, very few mechanistic data are available regarding host responses to H5N1 infection in astrocytes. In this study, a functional genomics approach was utilized to investigate comprehensive host responses to H5N1 infection in a human astrocyte cell line, U251 cells. U251 cells were infected by H5

ORGANISM(S): Homo sapiens

SUBMITTER: Lin xian 

PROVIDER: E-GEOD-66597 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress