Functional Networks Of Praziquantel-Induced Differentially Expressed Genes In Schistosoma mansoni And Synergy Of Omeprazole And Praziquantel In Vitro Against Adult Worms

ABSTRACT: Background: Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Therefore, there is a pressing need to explore the effects of PZQ on the parasites at the molecular level and to pursue alternative and/or or synergistic drugs against schistosomiasis. Methodology: We used a custom-designed Schistosoma mansoni oligo-microarray to explore the effects of a sublethal dose of praziquantel on S. mansoni adult worms’ gene expression. We used functional analysis of gene interaction networks to identify differentially expressed genes that are known targets of other drugs already tested in humans for diverse disease conditions. Omeprazole, a proton pump inhibitor drug that is widely prescribed, was tested in combination with praziquantel. We comparatively assesse

ORGANISM(S): Schistosoma mansoni

SUBMITTER: Giulliana Almeida 

PROVIDER: E-GEOD-66697 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress