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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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LRP8-Reelin-regulated Neuronal (LRN) Enhancer signature underlying learning and memory formation (GRO-seq)

ABSTRACT: A comprehensive landscape of epigenomic events regulated by the Reelin signaling through activation of specific cohort of cis-regulatory enhancer elements (LRN-enhancers), which involves the proteolytical processing of the LRP8 receptor by the gamma-secretase activity and is required for learning and memory behavior All GRO-Seq experiments were designed to understand the unique signature of LRN-enhancers and to evaluate the transcriptional response to Reelin treatment in neuronal cells.

ORGANISM(S): Mus musculus

SUBMITTER: Qi Ma

PROVIDER: E-GEOD-66703 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.

Telese Francesca F Ma Qi Q Perez Patricia Montilla PM Notani Dimple D Oh Soohwan S Li Wenbo W Comoletti Davide D Ohgi Kenneth A KA Taylor Havilah H Rosenfeld Michael G MG

Neuron 20150416 3

One of the exceptional properties of the brain is its ability to acquire new knowledge through learning and to store that information through memory. The epigenetic mechanisms linking changes in neuronal transcriptional programs to behavioral plasticity remain largely unknown. Here, we identify the epigenetic signature of the neuronal enhancers required for transcriptional regulation of synaptic plasticity genes during memory formation, linking this to Reelin signaling. The binding of Reelin to ...[more]

PMID: 25892301

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