Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis with no increased bleeding risk

ABSTRACT: Atrial fibrillation (AF) is a major risk factor for cardioembolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern particularly when antiplatelet treatment is simultaneously administered. Here, microarray analysis in peripheral blood cells in eight patients with AF and stroke and eight AF subjects without stroke identified a stroke related gene expression pattern. HSPA1B, which encodes for heat-shock protein 70 kDa (Hsp70), was the most differentially expressed gene. This gene was downregulated in stroke subjects, a finding confirmed further in an independent AF cohort of 200 individuals. Hsp70 knock-out (KO) mice subjected to different thrombotic challenges developed thrombo

ORGANISM(S): Homo sapiens

SUBMITTER: Jose Hermida 

PROVIDER: E-GEOD-66724 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress