Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Dual Roles of Histone H3 Lysine 9 Acetylation in Human Embryonic Stem Cell Pluripotency and Neural Differentiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Naihe Jing 

PROVIDER: E-GEOD-66779 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation.

Qiao Yunbo Y   Wang Ran R   Yang Xianfa X   Tang Ke K   Jing Naihe N  

The Journal of biological chemistry 20141217 4

Early neurodevelopment requires cell fate commitment from pluripotent stem cells to restricted neural lineages, which involves the epigenetic regulation of chromatin structure and lineage-specific gene transcription. However, it remains unclear how histone H3 lysine 9 acetylation (H3K9Ac), an epigenetic mark representing transcriptionally active chromatin, is involved in the neural commitment from pluripotent embryonic stem cells (ESCs). In this study, we demonstrate that H3K9Ac gradually declin  ...[more]

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