Dysregulation of Endometrial Inflammation Precedes the Development of Cytological Endometritis [mRNA]

ABSTRACT: The regulation of endometrial inflammation has important consequences for the resumption of bovine fertility post-partum. All cows experience bacterial influx into the uterus after calving; however a significant proportion fail to clear infection leading to the development of cytological endometritis (CE) and compromised fertility. We hypothesised that early immunological changes could not only act as potential prognostic biomarkers for the subsequent development of disease but also shed light on the pathogenesis of endometritis in the post-partum dairy cow. Here, next-generation sequencing from endometrial biopsies taken at 7 days post-partum (DPP) identified significant expression of inflammatory genes in all cows. Despite the common inflammatory profile and enrichment of the Toll-like r

ORGANISM(S): Bos taurus

SUBMITTER: Kieran Meade 

PROVIDER: E-GEOD-66825 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress