ALK-dependent transcription factor networks are associated with epigenomic alterations of DNA methylation in ALCL

ABSTRACT: Aberrant DNA methylation patterns of malignant cells allow for the study of the tumor phenotype and behavior, and can be used for tumor classification. Here, we describe the genome-wide DNA methylation signatures of a T cell lymphoma that is driven by the oncogenic fusion protein NPM-ALK. Differences in DNA methylation of tumor cells compared to normal T cells concern pathways that are implicated in T cell development and function and reveal a close relationship to thymic progenitor cells. We find DNA hypomethylation in regulatory regions that are enriched for conserved transcription factor binding motifs for NPM-ALK dependent transcription factors, such as AP1. Our results suggest a direct relationship of oncogenic signaling with epigenetic modifications via transcription factor induction

ORGANISM(S): Homo sapiens

SUBMITTER: Walter Pulverer 

PROVIDER: E-GEOD-66881 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress