Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: jinmiao chen
PROVIDER: E-GEOD-66970 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Immunity 20150401 4
Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth to generate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis. We show that YS MFs are the main precursors of microglia, while most other MFs derive f ...[more]