Microarray analysis of skeletal muscle in PGC1α transgenic mice

ABSTRACT: Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC1α) is a coactivator of various nuclear receptors and other transcription factors that shows increased expression in skeletal muscle during exercise. In skeletal muscle, PGC1α is considered to be involved in contractile protein function, mitochondrial function, metabolic regulation, intracellular signaling, and transcriptional responses. Several isoforms of PGC1α mRNA have recently been identified. PGC1α-a is a full-length isoform of PGC1α that was the first to be isolated. PGC1α-b is another isoform of PGC1α, which is considered to be similar in function to PGC1α-a, differing by only 16 amino acids at the amino terminus. We have previously generated independent lines of transgenic mice that overexpress PGC1α-a or PGC

ORGANISM(S): Mus musculus

SUBMITTER: Yukino Hatazawa 

PROVIDER: E-GEOD-67049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress