Transcription profiling of human U-2 osteosarcoma cell lines expressing different glucocorticoid receptor isoforms - time series

ABSTRACT: Glucocorticoids regulate diverse physiologic processes and synthetic derivatives of these natural hormones are widely used in the treatment of inflammatory diseases. However, chronic administration often triggers insensitivity and serious side effects including osteoporosis. The underlying mechanisms regulating these side effects are not completely understood. We report here that human osteosarcoma U-2 OS bone cells lacking the glucocorticoid receptor (GR) are resistant to glucocorticoid killing whereas the expression of wild-type GR activates an apoptotic program. Furthermore, we show that the translationally generated GR isoforms from a single GR gene have distinct abilities to induce apoptosis in these cells. Only cells expressing selective GR isoforms underwent apoptosis upon dexamet

ORGANISM(S): Homo sapiens

SUBMITTER: NIEHS Microarray Group 

PROVIDER: E-GEOD-6711 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress