Distinctive genotypes in infants with T-cell acute lymphoblastic leukaemia

ABSTRACT: Infant T-cell Acute Lymphoblastic Leukaemia (iT-ALL) is a very rare and poorly defined entity with a poor prognosis. We assembled a unique series of thirteen cases of infants with T-ALL which allowed us to identify genotypic abnormalities and to investigate prenatal origins. Matched samples (diagnosis/remission) were analysed by SNP-array to identify genomic losses and gains. In three cases, we identified a recurrent somatic chromosome 3 deletion. These losses, confirmed by FISH, result in the complete deletion of MLF1, not previously described in T-ALL. We observed two cases with an 11p13 deletion (LMO2-related), one of which also harboured a deletion of RB1. Another case presented a large 11q14.1-11q23.2 deletion that included ATM and only five patients (38%) showed deletions of CD

ORGANISM(S): Homo sapiens

SUBMITTER: Marcela Mansur 

PROVIDER: E-GEOD-67271 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress